A simple self-assembling system of melittin for hepatoma treatment
نویسندگان
چکیده
Abstract Background Hepatoma is a serious public health concern. New attempts are urgently needed to solve this problem. Melittin, host defense peptide derived from the venom of honeybees, has noteworthy hemolysis and non-specific cytotoxicity in clinical applications. Here, self-assembly melittin vitamin E-succinic acid-(glutamate) 12 (VG) was fabricated via noncovalent ?-stacking hydrogen bonding interactions using an environment-friendly method without “toxic” solvents. Results As expected, designed (denoted as M/VG nanoparticles) exhibits uniform morphology with particle size approximately 60 nm zeta potential ? 26.8 mV. Furthermore, added VG significantly decreased hemolytic activity, increased tumor-targeted effects, accelerated apoptosis. Conclusion Our research provides promising strategy for development natural self-assembled biological peptides application, particularly transforming toxic into safe therapeutic systems. Graphical
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ژورنال
عنوان ژورنال: Cancer Nanotechnology
سال: 2023
ISSN: ['1868-6958', '1868-6966']
DOI: https://doi.org/10.1186/s12645-022-00154-7